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KMID : 0613820160260111253
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Journal of Life Science
2016 Volume.26 No. 11 p.1253 ~ p.1258
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Effects of the Dried Root of Codonopsis pilosula on Gastrointestinal Motor Function in Mice
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Kim Min-Woo
Kim Hyun-Jin
Kim Moon-Moo
Lee Eun-Woo
Kwon Hyun-Ju
Kim Byung-Woo
Lee Hyun-Tai
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Abstract
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Although major advances have been achieved in our understanding and treatment of diseases in many areas of medicine, relatively few improvements have been made in the area of gastrointestinal (GI) motor function. The dried root of Codonopsis pilosula (Franch.) Nannf. (CP) has been used as a traditional folk medicine for improving poor GI function in East Asia, including China and Korea. In the present study, neither aqueous (CP-W) nor ethanolic (CP-E) extracts of CP showed significant toxicity, even at an oral dose of 5 g/kg to mice. The effects of CP-W and CP-E on GI motor function were investigated by measuring in vivo the gastric emptying rate (GER) and intestinal transit rate (ITR) in mice. In normal mice, the ITR was significantly increased by CP-W in a dose-dependent manner, whereas the GER was not significantly affected by any CP extracts. The ITR was significantly retarded in the mice with experimental GI motility dysfunction (i.e., peritoneal irritation by acetic acid) compared with that in normal mice. However, the retardation was significantly recovered by the pretreatment of CP-W in a dose-dependent manner. The above results suggest that CP-W might be a potential prokinetic agent preventing or alleviating GI motility dysfunctions in human patients.
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KEYWORD
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Codonopsis pilosula, gastric emptying, gastrointestinal motor function, intestinal transit, prokinetic agent
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